Журнал анестезиологии и исследований боли

Unraveling the Role of IRF8 Polymorphisms in Systemic Sclerosis Development and Pathogenesis

Abstract

Naomi Alonso

Systemic Sclerosis (SSc) is a complex autoimmune disease characterized by fibrosis of the skin and internal organs, vascular abnormalities, and dysregulation of the immune system. The etiology and pathogenesis of SSc involve intricate interactions between genetic predisposition and environmental factors. Recent studies have highlighted the potential involvement of Interferon Regulatory Factor 8 (IRF8) polymorphisms in the development and pathogenesis of SSc. IRF8 is a critical transcription factor involved in the regulation of immune responses, including the differentiation and function of dendritic cells and macrophages. This review aims to unravel the role of IRF8 polymorphisms in SSc susceptibility, clinical manifestations, disease progression, and treatment response. Understanding the genetic variations in IRF8 and their impact on immune dysregulation in SSc may provide valuable insights into disease mechanisms and facilitate the development of targeted therapies.