Журнал биомедицинских и фармацевтических наук

Frontotemporal Dementia (FTD) is a devastating neurodegenerative disorder characterized by progressive deterioration of behavior, language, and executive functions. As one of the most common forms of early-onset dementia, FTD poses significant challenges to affected individuals, their families, and society at large. This paper presents an evaluation assessment of "Where Is Us Now" in Frontotemporal Dementia, aiming to explore the current state of knowledge, research, and management strategies surrounding this complex condition. Through a comprehensive analysis of existing literature, clinical studies, and emerging therapies, this assessment seeks to shed light on the progress made in understanding FTD and its impact on individuals and their communities.

The field of medicinal chemistry plays a vital role in the discovery and development of new drugs and therapeutic agents. However, traditional drug development approaches often rely on the extensive use of synthetic chemicals, leading to adverse environmental impacts and potential harm to ecosystems. In response to growing concerns about ecological sustainability, researchers and pharmaceutical industries have started exploring innovative methods for designing and synthesizing ecologically friendly medicinal materials. This review aims to provide an in-depth analysis of the current state of research in this emerging area and highlights novel approaches that offer promising alternatives to conventional drug design and synthesis. Medicinal chemistry is a multidisciplinary field that involves the design, synthesis, and evaluation of bioactive compounds with potential therapeutic properties.

Cancer is a complex and devastating disease that continues to be a global health challenge. Despite significant advancements in cancer research and treatment modalities, traditional therapies often suffer from limited efficacy and severe side effects. Nanomedicine has emerged as a promising approach to revolutionize cancer treatment by utilizing nanoscale materials to deliver therapeutic agents with high precision and efficacy. This article explores the current state of cancer nanomedicine, novel methods employed in the field, and the medical opportunities it presents for improving cancer management. Cancer remains one of the leading causes of mortality worldwide. Conventional cancer treatments, such as chemotherapy, radiation therapy, and surgery, have shown some success but are often associated with severe side effects due to their non-selective nature.

Arboviruses, or arthropod-borne viruses, represent a significant global public health concern due to their ability to cause widespread human infections. These viruses are primarily transmitted to humans through the bites of infected mosquitoes, making these vectors essential players in the arbovirus transmission cycle. Mosquitoes have developed an intricate immune system to combat invading pathogens, including arboviruses. Research in recent years has shed light on how the mosquito's systemic immune response plays a crucial role in the detection and control of arboviral infections. Understanding this process can provide valuable insights into developing innovative strategies for controlling arboviral diseases. This article explores the mechanisms behind how arboviruses are detected through the mosquito's systemic immune response and its implications for public health.

World Health Organization supported pharmacists in international context and recommended one pharmacist per 2000 population and per 50 beds worldwide. Relationship between physician, nurse and pharmacist existed in triangle and every angle of triangle has their own importance if any of angles is deficient the health team will incomplete. Paradigm shift in pharmacy practice from mercantile products oriented practice to patient oriented. In Pakistan this is not up to the required level and this indicator is not followed up to the marked to improve the health care team triangle ultimately provide rational drug therapy to the patient. That’s why we can called as fragile health team triangle. The current article through light on current scenario on scope of pharmacists in Pakistan and the main aim of this study is to synergize, facilitate and hire these specialists in order to stabilize the health care team triangle.

Human cells produce an enormous number of proteins and dysfunction in these may lead to serious diseases and developmental abnormalities. To treat these protein de iciencies the missing or dysfunctional molecules are complemented or substituted with therapeutics provided by different biological systems. However, protein therapeutics must unavoidably adhere to quality constraints that are much stricter than those for chemical industries. Although it is undoubtedly a challenging task to obtain an active protein in a way that is economically feasible, biopharmaceuticals (recombinant proteins, monoclonal antibodies or vaccines) are the largest group of drugs developed in the pharmaceutical industry. Market calculations estimated the recombinant protein drug industry to be around 10% of the entire drug market, predicting an even larger proportion in the future. The global market of biopharmaceuticals is estimated to grow at a Compound Annual Growth Rate (CAGR) of 13.8% from 2018 to 2025, according to the latest report developed by allied market research. The report biopharmaceuticals market by type and application: Global opportunity analysis and industry forecast, presenting an analysis of pro iles of the major player projects that the global biopharmaceuticals market, which reached $186,470 million in 2017, will have reached $526,008 million by 2025. The more detailed characteristics of the expected value growth of particular biologic types in the biopharmaceuticals market (divided into dominating monoclonal antibody, growth and coagulation factor, interferon, vaccine, insulin, erythropoietin and hormone) are available in the report and on the allied market research website.