Журнал клинических респираторных заболеваний и ухода: открытый доступ

A 36-year old patient with relapsing T-cell prolymphocytic leukemia was admitted in intensive care unit for acute respiratory failure and pulmonary infiltrates. A flexible bronchoscopy with bronchoalveolar lavage was performed while the patient was under noninvasive ventilation. Cytological examination and immunophenotyping of BAL lymphoid cells confirmed the diagnosis of lung infiltration with prolymphocytic T-cell leukemia. An associated organized pneumonia was suspected. The rapid clinical and radiological response to corticosteroids followed by immunotherapy with alemtuzumab strengthened our hypothesis. To our knowledge, this is the first reported case of prolymphocytic T-cell leukemia with a specific pulmonary lung involvement associated with an organized pneumonia.

In past decades, acute respiratory distress syndrome (ARDS) has been associated with high mortality and morbidity. Although many maneuvers have been tested including tens of clinical trials, so far there is still no approved pharmacological intervention available for ARDS except protective ventilation strategy. Mesenchymal stem cells (MSCs) has shown improved survival in various ARDS animal model after administration. Here we summarized the updates of MSC derivation and purification, administration approaches, timing of MSC delivery, and mechanism of MSC therapy in order to provide a state-of-art paradigm of cell based therapy in ARDS and to facilitate the development of MSC therapy in ARDS patients.

Background: It has been known that smoking is the primary causative factor of lung cancer, but other factors also play roles. Epidemiological studies demonstrate an increase of cancer in people lower exposure to sunlight and which has an impact in the synthesis of active 25(OH)D. The aim of study was to determinate the potential role of 25(OH)D etiologic factor in subtypes of lung cancer. Methods: There were 140 participants of which 100 were men (71.4%) and 40 (28.6%) were women. The study group was 60 lung cancer before any treatment participants (48 male, 12 female) and control group was 80 (52 male, 28 female). The study group was divided into three histologic subtypes; small cell lung cancer (SCLC) (13 pts, 21.7%), squamous cell lung cancer (SqCC) (18 pts, 30%) and non-squamous (23 adenocarcinoma, 6 others; total 29 pts, 48.3%). Results: There was significant difference between smoking and histologic subgroups (p<0.001). While the SCLC (p=0.002) and the SqCC (p<0.001) group had a significantly more pack/year smoking; no difference in non-squamous subgroup (p=0.114). 25(OH)D levels was significantly less in non-squamous cell subgroups (p<0.001). Smoking group has less 25(OH)D levels than non-smoker group significantly (p=0.006). Conclusion: Meanwhile smoking is a risk factor for SCLC and SqCC; in non-squamous subtype 25(OH)D deficiency could be a causative factor. Our findings may be supported with further studies including larger patient populations.

Purpose: Sleep disorders have become epidemic throughout the worldwide, at the same time due to Multiple social changes, the same thing can be said for the vitamin D deficiency disorders, including the use of air conditioning and sunscreen, have produced a world-wide epidemic of vitamin D deficiency, then taking in consideration the proposed concept that since vitamin D plays an important role in the brainstem control of sleep, which is supported by the presence of vitamin D receptors in same areas are considered to play a role in the initiation and maintenance of sleep, this relation may not be strong as causative association but presence of either may have worsening effect on the other. Methods: The aim of our study was to investigate the prevalence of between serum 25-hydroxy [25 (OH)] vitamin D levels and severity of disease in patients with OSAS, among the cosmopolitan (multi-national) population of Dubai, United Arab Emirates. Two hundred and sixty nine (269) patients were included in the study, all who were referred to the sleep clinic at Rashid hospital – Dubai health Authority, during the period of three years from 2012 to 2014. Serum 1-25 Di Hydroxy Chole Caciferaol (vitamin D), were evaluated. Results: Among the 148 patients who had OSA; those who were vitamin D deficient represent 16.1% of the Mild OSA group, 7.3% of the moderate OSA group and 7.9% of the Severe OSA group, while at the same time those who were vitamin D insufficient represent 29% of the Mild OSA group, 39% of the moderate OSA group and 31.6% of the Severe OSA group. Conclusions: When the severity of OSA increases, then vitamin deficiencies, becomes more pronounced(but not significant), Thus subjects with more severe OSA indices tended to present lower vitamin D levels; furthermore Vitamin D deficiency may play a role and/or worsen OSA’s. We need to study more OSA adverse outcomes on glucose metabolism, in relation to vitamin D deficiency & insufficiency, as may be considered for supplementation treatment.