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Объем 6, Проблема 3 (2014)

исследовательская статья

Физические упражнения и добавки с маслом печени акулы снижают рост опухолей и раковую кахексию у крыс Walker 256 с опухолями

??????? ??????, ??????? ??????????, ??????? ????, ??????? ?????? ??????, ??????? ?? ???????, ???????? ??????? ???????? ?? ?????, ??????? ??????, ???? ?????????, ????? ?.?. ?????????, ??????? ?. ????????? ? ???? ??????? ?????????

? ???? ???????????? ?????????, ?????? ?? ??????????, ????????? ? ??????????? ????? ?????? ????? (1 ?/?? ????? ????/????), ?? ???? ???????, ????????, ?????????? ????????? ??????? ? ?????????? ??????, ??????????? ? ?????? ?????? ? ???? Walker 256 ? ?????????. ???????? ???? ????????? ?? 4 ??????: ????????????? ???????? ??????? (W), ????????????? ???????? ??????? ? ??????????? ????? ?????? ????? (WSL), ????????????? ???????? ??????? (EW) ? ????????????? ???????? ??????? ? ??????????? ????? ?????? ????? (EWSL). ????????????? ?????? ???????? ?? 6 ???????? ?? 30 ?????? ?????? ? ?????? ? 50% ???? ????, ????????????? ? ????????, ?? ??????? ????????? 1 ?????? ?????? (????????? ??????????). ????? ???? ????? ????? ???????? ????????? ?????????? ?????? ?????????? ???????????? 30-????????? ???????????? ???????? ? ??????, ????????????? 6% ???? ????, 4 ???? ? ?????? ? ??????? 8 ??????. ?????????? ?????? ??????? ?? 6-? ?????? ??????????, ? ??? ?????? ???? ????? ????? 15 ???? ????? ??????????. ??? ??????? (?) ? ?????? W ???????? 26,50 ± 1,79, ? ? ??????? WSL, EW ? EWSL — 14,08 ± 0,91, 15,60 ± 0,55 ? 12,60 ± 1,07 ??????????????. ? ?????? W ??????????? ???????????? (68,67 ± 2,12 ??/??), ????????????????? (1,49 ± 0,06 ?????/?), ???????????????????????? (161,4 ± 9,4 ??/??) ? ???????? ????? ???? (13,21 ± 2,25 ?), ??? ????????????? ????????? ????????. ? ??????? WSL, EW ? EWSL ??????????? ???????? ???????????? ?????????? ?????? ex vivo, ? ????? ??????????? ????????? ?????????????? ? ???????. ??????????? ?????????? Bax/Bcl-2 ?????????? ?????? ? ???????, ??????????? ??????????. ??????? ? ?????? ?????? ????? ? ?????????? ?????????? ???? ?? ???? ?????? ????????????? ???????? ????????? ????????, ? ????? ????????? ???? ???????, ?? ????????? ????? ???????? ????????? ?????????? ??????????? ?????? ?? ???? ???????.

исследовательская статья

Экспрессия CD133 коррелирует со стадией опухоли, метастазами в лимфатические узлы и рецидивом плоскоклеточного рака полости рта

??????? ??????? ?, ???????? ?, ?????????? ?, ?????? ?, ?????? ?, ??????? ?, ????? ?, ????????? ?, ??????? ?, ?????? ? ? ???????? ?

????: CD133 ???????????? ????? ????????????? ?????????? ?????, ??????????????? ??? ??????????? ???????? ?????????? ???????? (CSC) ? ??????????? ????? ???? ? ????????. ????? ??????? ???????????? ???? ???????????????? ?????? ?????????? CD133 ? ???????? ???? ??????? ??? ? ??????? ??? ????? ? ????????? ???????????.
??????: ?????????? ????? CD133 ??????????? ? ??????? ????????????????? ? ????? ??????????????? ???????? ??????? ??? (OSCC), ? ???? ???????????????? ?? ????? ? ????????????? ???????????????? ???????????? ? ??????????? ??????? ? ?????????.
??????????: ?????????? CD133 ?????? ??????????? ????? ?????? ???????? ?? ??????? ????????? ????????????? ?????? 5 (???????? 0–80; ??????? ???????? = 11), ? ??????????? CD133 ?? ???? ?????????? ? ?????????? ??????? ? 29 (43%) ???????. ?? ??????????? ?????????? ? ????????? ?? ?????? ?????????? ????????, ????? ? ???????? ?????????????????, ????? ??? ???????????? ?????????? ??????????? ?? ??????? ???????. ?????? ???????-?????? ????????????? ???????????? ???????? ???????????? ?????????? ????? ?????????????? ? ?????????????? ???????? ????????? (p = 0,001 ?? ???????????? ?????), ?? ??????????? CD133 ?? ???????????, ??? ???????? ??????????? ??????????? ???????????? ?????? ? ??????????? ???????.
??????????: ?????????? CD133 ???? ?????????? ? ??????????? ???????? OSCC ? ??????????? ????????????? ?? ??????? ??????? ? ??????????? ??????? ????????? ? ????? ?????? ????????????? ????????????. ?????????? ?????????? ???????????? ?? ????? ??????? ?????? ??????? ??? ????????? ???? CD133 ? ???????? ? ???????????????? OSCC ? ??? ??????????? ? ???????? ???????????????? ??????????.

исследовательская статья

Фрактальная и евклидова геометрическая диагностика цитологии шейки матки

?????? ???????? ????????, ???? ??????, ???????? ??????, ???????? ???? ? ????? ?????

???????????: ???????????? ?????? ?????? ????????? ????? ????? ????????????? ???????? ? ??????????????????. ??? ??????? ???? ???????? ???? ??????????? ??????????????? ???????????, ?????????? ?? ??????????? ? ?????????? ?????????, ????????????? ???????????????? ????????????, L SIL ? H SIL.
????: ????? ????????? ?????? ???????? ????????????? ??????????? ???????????? ????? ??????????? ? ?????? ????????????.
??????: ??????????? ??????? 15 ?????????? ??????, 15 ASCUS, 15 L SIL ? 15 H SIL ??? ????????????. ????????? ???? ??? ?????????? ??????????? ????? ??????? ??????????? ???????????, ?????????? ???????????, ?????????? ????????, ? ?????????? ????????, ?????????? ???????????? ??????? ???????. ?????????????? ??????? ??? ?????????? ? ??????? ? ???????????? ?????????, ???????? ?????????????, ????????????????, ????????????? ????????? ????????????? ? ??????????? ?????.
??????????: ???? ??????????, ??? ????????????? ????????? ??????? ??????????? ? ????????? ????? ????????? ?????????? ? ???? ???????? ? ?????????????? ????????????, L SIL ? H SIL. ??? ???????? ????????????????, ??? ? ???????? ????????????? ?????????? 100 ?????????. ??????????? ????? ??? ????? 1, ? ????????????? ????????? ????????????? ???? ????? ????. 4 ASCUS ???????? ?????????????? ???? ????????????, ? ?? ????? ??? ?????????? 11 ???????? ???????? ?????? L-SIL.
??????????: ?????????????? ??????????? ????????? ???????? ??? ??????????? ?????? ????????? ????? ?????, ?????????????? ?????, L SIL ? H SIL, ?????????????? ?????? ????, ????????? ?????? ?????? ? ????? ??????? ?????? ???????, ? ?????????? ???????????????? ?????? ASCUS.

Обзорная статья

Взаимоотношения между Toll-подобными рецепторами и иммуноглобулинами, ассоциированными с RP215, экспрессируемыми раковыми клетками

??????? ??, ???-???? ????, ??? ???? ? ???? ???

??????????????? ????? ??????????? ???????????????? ???????? ???????? ? ??????????? ????-???????? ?????????? ???? ??????????? ? ??????? ????????????? ???????????? ????????? ????? ??? ????????? ?? ???? ? ?????????? ???????? ? ??????????? ????. RP215 — ??? ?????????????? ????????, ????????? ? 1987 ????, ? ???? ??????????, ??? ??? ?????????? ????????? ? ?????????? ??????, ??????? ?????????????? ??????????????? ? ??????? ????? ????????????????, ??????????????? ???????? ????????, ?? ?? ? ?????????? ???????? ???????. ? ???? ?????? RP215 ????????????? ??? ???????? ?????????????? ??????? ???????????????? ? ????-????????? ??????????? ?? ?????????? ?????????? ??????? ??????. ? ????????????? ????????? ????? ? ?????????????? ????? ?????? ???? ???????? OC-3-VGH ? ????? ????? C-33A ???? ????????, ??? ?????????? ??????? ????-???????? ?????????? (TLR-2, -3, -4, -6, -7 ? -9) ?????? ??????? ?? ????????? ??????? ?????? ? RP215 ??? ?????????? ?????? ????????????? IgG. ????????, ??? RP215, ??? ? ???????????????? IgG ???? ?????????? ? ??????? ?????????? ??? ????????? ?????????? TLR-3 ? 2,5 ? 3,5 ???? ??????????????, ????? ??? TLR-4 ? TLR-9 ???? ???????? ?? 50% - 80% ? ?????????. ??????????? ?? ???? ?????????????, ??????? ????????????, ??? ??????? ??????????????? ??????? ????????? ? ????????? ??????????? ?????????? ??????? ??????, ????? ?????????? ????/???????????? ??????? ?????? ? ????????? ????????.

исследовательская статья

Chronic Low Level Arsenic Exposure Inflicts Pulmonary and Systemic Inflammation

Dona Sinha, Bidisha Mukherjee, Banani Bindhani, Kaustav Dutta, Hirak Saha, Priyanka Prasad and Manas Ranjan Ray

Objective: To examine whether chronic low level arsenic (As) exposure (11-50 μg/L) from drinking water elicits inflammation and oxidative stress.

Methods: Never-smoking pre-menopausal women (n=267) from Nadia district, West Bengal, India, were enrolled into two groups (i) control (n=122, median age 39 yr) from villages with <10 μg/L of As in groudwater, and (ii) exposed (n=145, median age 38 yr) from the same district where the groundwater As was 11-50 μg/L. As in water was measured by atomic absorption spectrophtometry with vapour generation assembly. Sputum cytology and hematology were done by standard procedures. Enzyme-linked immunosorbent assays were used to measure tumor necrosis factor-alpha (TNF-α), interleukin-6, 8, 10, 12 (IL-6, IL-8, IL-10, IL-12) and C-reactive protein (CRP) in plasma and cortisol in serum. Serum nitric oxide (NO) was measured colorimetrically, myleperoxidase (MPO) and neutrophil elastase by spectrophotometry, reactive oxygen species (ROS) by flow cytometry, and inducible nitric oxide synthase (iNOS) by immunocytochemistry.

Results: As level in groundwater was higher in endemic areas (28.32 ± 13.51 vs. 2.72 ± 1.18, p<0.05), and exposed women had lower hemoglobin, leukocyte and erythrocyte levels but elevated platelet count than control and their sputum contained increased number of alveolar macrophages and inflammatory cells. In addition, they had elevated levels of TNF-α, IL-8, IL-6, IL-12, CRP, cortisol and NO but depleted level of IL-10 with excess generation of ROS and increased expression of iNOS in the airways. Neutrophils of As-exposed subjects had elevated levels of MPO and elastase. After controlling education and family income as potential confounders, the rise in pro-inflammatory mediators in blood and excess generation of ROS in the airways were positively associated with as levels in ground water.

Conclusion: Drinking of water contaminated with low level of as for long causes pulmonary and systemic inflammation and generates excess ROS in the airways.

Обзорная статья

Cancer – Could it be Cured? A Spontaneous Regression of Cancer, Cancer Energy Metabolism, Hyperglycemia-Hypoglycemia, Metformin, Warburg and Crabtree Effects and a New Perspective in Cancer Treatment

Oleksyszyn Jozef, Joanna Wietrzyk and Mateusz Psurski

The spontaneous regression of cancer is still a mysterious phenomenon but an understanding of it, at least partially, could lead to new and better cancer treatment. On the basis of new data concerning cancer energy biochemistry, the authors here present a hypothesis to understand and explain the phenomenon of the spontaneous regression of cancer, together with its implications for new approaches to cancer treatment. Such treatment involves the manipulation of the energy metabolism and/or redox status of cancer cells.

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