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Журнал воспалительных заболеваний и расстройств кишечника

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Объем 5, Проблема 2 (2020)

Краткое сообщение

Role/Risks of Proton Pump Inhibitors and Infliximab in IBD Patients

Lim Vuanghao

Proton Pump Inhibitors (PPIs) are the most generally endorsed class of medicine for the treatment of indigestion and corrosive related issues. They work by obstructing the site of corrosive creation in the parietal cell of the stomach. Infliximab, a chimeric monoclonal antibody, is a medication used to treat a number of autoimmune diseases mainly Ulcerative Colitis (UC) and Crohn's Disease (CD). Infliximab targets TNF, thought to be more related to Th1 cytokines.
Перспектива

Clinical and Socio-Demographic Characteristics of Inflammatory Bowel Disease Patients in Gaza: A Cross-Sectional Descriptive Study

Khamis Alessi, Hamza Yazji, Fekri Hamad, Saed Ouda, Mohammed Alkhatib and Qusay Abdoh

Background:The global incidence of Inflammatory Bowel Disease (IBD), Ulcerative Colitis (UC) and Crohn's Disease (CD), is in the rise. Despite the presence of some international studies that described the different patterns and characteristics if IBD, still however, we don't have a national epidemiological or descriptive data especially in Gaza Strip. The aim of this study is to identify socio-demographic and clinical characteristics of IBD among patients with IBD in Gaza.

исследовательская статья

Use of Narrow Band Imaging Colonoscopy in Diagnosis of Ulcerative Colitis Patients

Khaled A. Aaty, Ayman Shamseya, Ezzat Aly, Moamen A. Fawzy and Reem Ezzat

Ulcerative colitis is a disease of increasing incidence and may progress to colonic cancer. Early detection of dysplastic changes is required. NBI is an added imaging procedure that is supposed to increase the yielding of diagnosis of ulcerative colitis.

Aim of the study: Validate the relation between histological pattern and NBI findings in diagnosing ulcerative colitis.

Patients and methods: 50 patients with diagnosed ulcerative colitis in Alexandria University Hospital were examined by colonoscopy and NBI then biopsies were taken from areas with detected lesions and histopathological examination was done.

Results: Patients were divided into active (27) and inactive (23) according to the clinical performance. From the 23 patients that were supposed to be inactive, 14 showed honeycomb appearance and 7 showed irregular vascular mucosal patterns by NBI examination. Histopathological examination revealed metaplasia in 55% of the patients that were under the category of inactive patients. There was a significant correlation between histological examination and NBI findings. NBI showed sensitivity of 58.3%, specificity of 100%, PPV of 100%, NPV of 23% and accuracy of 62.9% in active patients.

Conclusion: NBI is a valuable tool that can add value to colonoscopic examination in patients with ulcerative colitis.

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