Клинические инфекционные болезни: открытый доступ

Advancing the Battle against Surgical Wound Infections: Unveiling the Complexities of Biofilm Formation and Pioneering Strategies for Effective Treatment and Prevention

Abstract

Michal Ulrikka

Surgical wound infections pose a significant challenge in healthcare settings, contributing to patient morbidity, prolonged hospital stays and increased healthcare costs. Among the intricate factors that contribute to the persistence and severity of these infections is the formation of biofilms. Biofilms are complex communities of microorganisms that attach to surfaces and form a protective matrix, making them highly resistant to conventional antimicrobial therapies. Understanding the complexities of biofilm formation and developing innovative strategies for their prevention and treatment are crucial in advancing the battle against surgical wound infections. The inherent resistance of biofilms makes them notoriously difficult to eliminate, leading to chronic infections and recurrent wound complications. Moreover, biofilms can develop on a variety of medical devices, such as surgical implants, catheters and wound dressings, further complicating the management of surgical wounds.