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In Healthy Humans, Chronic Physiological Hyperglycemia affects Insulin Ability to Reduce the Level of Glucagon in the Blood

Abstract

Dario Pitocco

Type 2 diabetes mellitus is characterised by hyperglucagonemia. We looked at how insulin and hyperglycemia, both of which are common in those who can tolerate glucose normally, affected the suppression of plasma glucagon levels. Hyperglucagonemia contributes to fasting as well as postprandial hyperglycemia in type 2 Diabetic mellitus. Multiple studies have shown that impaired suppression of glucagon following a meal is a characteristic feature of type 2 diabetes mellitus and contributes to the hyperglycemia.