Архив хирургической онкологии

The Role of Surgery in Metastatic Melanoma: A Comprehensive Review of Molecular Characteristics

Abstract

Hika Choe*

Metastatic melanoma represents a formidable challenge in oncology due to its aggressive nature and propensity for spreading to distant sites. While systemic therapies have revolutionized the management of metastatic melanoma, surgical interventions remain integral components of treatment strategies. This article provides a comprehensive overview of the role of surgery in metastatic melanoma, highlighting recent advancements in understanding melanoma's molecular characteristics and their implications for surgical management. One significant advancement is the recognition of the importance of complete surgical resection in achieving optimal outcomes for patients with metastatic melanoma. Surgeons strive to achieve clear margins while minimizing functional and cosmetic impact, often utilizing techniques such as Mohs micrographic surgery or sentinel lymph node biopsy to enhance precision and minimize tissue damage. Moreover, the advent of minimally invasive surgical techniques has expanded treatment options for metastatic melanoma patients. Procedures such as laparoscopic or robotic-assisted surgery offer the potential for faster recovery times, reduced postoperative pain, and improved cosmetic outcomes compared to traditional open surgery.