Журнал онкологических трансляционных исследований

Fluoropyrimidines (FU) (5-fluorouracil, capecitabine and the oral prodrug tegafur {not marketed in Saudi Arabia) are a commonly used chemotherapeutic agents to treat a wide variety of cancers. Fluoropyrimidines are used as the basis of adjuvant and  palliative treatment for colorectal, oesophago-gastric, breast and head and neck cancers. In addition, there is increasing use of the same group of drugs in pancreatic cancer and hepato-biliary malignancies. Treatment with fluoropyrimidines is well tolerated. However, severe adverse drug reactions have been recognised to occur in 5%-10% of the treated population. A considerable proportion of adverse drug reactions are likely to be the result of inter-individual genetic variation.

Background: Verrucous carcinoma or Ackerman’s tumor comprise 2% to 5% of oral cancer malignancies. It has a higher prevalence
in patients with use of Tobacco and related products. It is also associated with HPV infection. It is more common in middle aged and elderly
individuals. verrucous carcinoma is a locally proliferative disease and does not metastasize. It will not invade the underlying bone and
muscles and as such it is localized to mucosa. The verrucous carcinoma has the propensity to turn carcinomatous if not treated for a long
time. Histopathologically it is characterized by dysplasia without invasion of underlying dermis. Verrucous carcinoma is conventionally
treated by a mutilating surgery or radiation. Both these options have side effects which are not acceptable to patients. Laser gives an
easier way to handle this condition without any of side effects of above procedures. This was a retrospective analysis of verrucous
carcinoma cases where treatment was given in the form of laser ablation of the growth. Laser was used to ablate the visualized tumor and
followed up with minor ablative sessions. Sites included were buccal mucosa 50%, RMT area with buccal mucosa 15%, Tongue 25%, 10%
had on genitalia. No radiation or any other chemotherapy was administered.