Журнал фармакогнозии и натуральных продуктов

Antidiabetic Activity of Flavonoid from Binahong Leaves (Anredera cordifolia) Extract in Alloxan Induced Mice

Abstract

Ratna Djamil, Wiwi Winarti, Sarah Zaidan and Syamsudin Abdillah*

Objective: To evaluate antidiabetic activitiy of flavonoid from binahong (Anredera cordifolia) leaves.

Method: α-glycosidase enzyme inhibiting activity was tested in vitro and antidiabetic activity in alloxan-induced mice.

Results: The research shows that ethyl acetate extract of binahong leaves had α-glycosidase enzyme inhibition of 81,23 μg/mL. Isolation of active compounds in binahong leaves successfully identified flavonoid compound of 8- Glucopyranosyl-4',5,7-trihydroxyflavone, which is also known as 8-Glucopyranosylapigenin. 8-Glucosylapigenin that is also popularly known as Orientoside was found to have α-glycosidase enzyme inhibiting activity with IC50 value of 20, 23 μg/mL and have an ability to decrease blood glucose in alloxan-induced mice.

Conclusion: Ethyl acetate extracts of binahong (Anredera cordifolia) leaves contain flavonoid compound of 8- Glucopyranosyl-4',5,7-trihydroxyflavone, which is also known as 8-Glucopyranosylapigenin, 8-Glucosylapigenin, which is able to decrease blood glucose and inhibit enzim α-glycosidase enzyme.