Журнал спортивной медицины и допинговых исследований

Molecular and Epigenetic Mechanisms in Opioid Receptors: Implications for Drug Addiction and Pain Management in Sports

Abstract

Daniela Wagner*

This paper investigates the intricate molecular and epigenetic mechanisms underlying the function and regulation of opioid receptors, with a particular focus on their implications in drug addiction and pain management within the realm of sports. Opioid receptors play a crucial role in mediating the effects of endogenous opioids as well as exogenous opioids, such as prescription painkillers or illicit drugs, like heroin. The interplay between these receptors and their ligands in the central nervous system contributes to both the rewarding effects of opioids and the development of addiction. Recent advancements in molecular biology and epigenetics have shed light on the complex mechanisms that modulate opioid receptor expression and function. Epigenetic modifications, including DNA methylation, histone modifications, and non-coding RNAs, have been identified as critical regulators of opioid receptor gene expression. Moreover, these epigenetic modifications can be influenced by environmental factors, such as chronic pain or drug exposure, and may contribute to the individual variability observed in opioid responses and susceptibility to addiction.