Журнал генетики и исследований ДНК

Transgenic Mice Brain ; Imaging Studies of Alzheimer's disease

Abstract

Chenn Jenn-Tzong

Alzheimer sickness PET imaging specialists dependent on lipophilicity change are [18F] RO6958948 [1] and [18F] Florbetapir, plan by supplanting with a Nitrogen component either in the fragrant ring of [18F] Flortaucipir or [18F] Florbetaben. The structure of [18F] FEONM (is intended to give higher lipophilicity than [18F] FDDNP. Structure alteration on a specific bioactive atom to expand its lipophilicity will be likewise potentially expanding the level of infiltrating blood cerebrum obstruction. Expanding the blood cerebrum obstruction crossing proportion, the particularity of this dynamic biomolecule focusing on impact may be diminished. Along these lines, we plan an ethyl oxide changed naphtha based Alzheimer infection positron outflow tomography imaging specialist [18F] FEONM, to think about the take-up impact of Tau tangle and Beta amyloid. PET radiopharmaceuticals for mind imaging depend on extremely short half-life radionuclides, the vast majority of them will be rotted in one day. One of the longest half-life natural radionuclides is fluorine-18, in this way basic advance to creating PET radiopharmaceuticals online is radio fluorination response. The most elevated radio fluorination response yield can be produced using carboxyl glass reactor. In carboxyl glass reactor, the capacity of whole territory (FG) bend of radio fluorination yield can be drawn nearer with Gauss dispersion, Gauss or Welch anodization work. After decide the radio fluorination rate consistent, the length of microfluidic plug stream reactor can be planned with an expository structure dependent on Welch anodization work. Mind hippocampus imaging relative explicit restricting proportion of [18F] FEONM on a Tau tangle P301S/PS19 transgenic mouse model is double cross higher than cerebellum, Beta amyloid Tg2576 transgenic mouse model is under two. On a triple transgenic 3xTg mouse model with both Tau tangle and Beta amyloid framed, the take-up proportion of hippocampus is 50% higher than cere In addition, other than transgenic mouse model, streptozotocin actuated Tau tangle mouse model likewise shows higher cerebrum hippocampus [18F] FEONM take-up than control mouse. From the transgenic mouse model imaging study, we discovered [18F] FEONM will take up on both Tau tangle and Beta amyloid transgenic mouse. In contrast with [18F] FDDNP, it shows no Beta amyloid transgenic mice take-up in mind hippocampus. This outcome speaks to part of the particular authoritative of Tau tangle transgenic mouse of [18F] FDDNP has move to Beta amyloid. In this manner, Tau tangle and Beta amyloid take-up status should be possible by [18F] FEONM in a similar time for conclusion Alzheimer illness. Radiation presentation will be half measurement contrasted with taking both imaging. These discoveries dependent on another plan presume that another PET radiopharmaceutical configuration has a similar idea like another radio fluorination microfluidic reactor plan. Either another synthetic structure or another numerical model contributes an accomplishment.