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Журнал генетики и исследований ДНК

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Объем 5, Проблема 5 (2021)

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Generation of long acting therapies using glycosylated linkers

Abdulrahman Alshehri, R J Ross and I R Wilkinson

Rationale: The current therapeutic drugs such as, growth hormone (GH), granulocyte colony stimulating factor (GCSF) and leptin require once daily injections, which are inconvenient and expensive.

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The genetics of common diseases

Kari Stefansson

At deCODE genetics in Iceland we have sequenced the whole genomes of 50.000 Icelanders or 12.5% of the nation and genotyped 180.000 or 60% of the nation.

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Epigenetic regulation of leukemia

Andreas Lennartsson

Acute myeloid leukemia (AML) has a poor prognosis in both adults and children, with a long-term survival of only 25% and 60% respectively. No major development has occurred of the treatment since, the last decades and the majority of treatments for AML consist of cytotoxic drugs with low specificity.

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Targeting a lncRNA �¢?? Epigenetic factor complex to inhibit colon cancer metabolism

Maria Hatziapostolou

LncRNAs (long non-coding RNAs) have recently occurred as new epigenetic regulators contributing to human diseases. We found that the lncRNA HOTAIR is up-regulated in colon cancer and associates with poor patient survival.

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Evaluating drug-chromatin interactions using novel methods for target engagement studies

Marta Rucka

Regulation of gene expression is a dynamic process orchestrated and maintained by a large variety of chromatin-interacting proteins. Understanding these chromatin-protein complexes and their binding kinetics is crucial for development of the small-molecule drugs. Promega has developed NanoBRET technology, which allows for dynamic measurement of protein:protein interactions (PPIs) in living cells.

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