Журнал метаболического синдрома

Retinol Binding Protein 4: Possible Relation between Insulin Resistance in Type 2 Diabetes and Visceral Obesity

Abstract

Alyaa Ahmed  Elsherbeny, Emad Abdel Mohsen Abdel Hady, Amira Ramadan Elmahdi

Introduction: Retinol Binding Protein 4 (RBP-4), an adipokine, that was identified as key regulator of obesity related insulin resistance and type 2 diabetes, and certain components of metabolic syndrome. Objectives: To study the relation of RBP4 and insulin resistance in patients with visceral obesity and type 2 diabetes mellitus. Patients and Methods: This study was conducted on 74 subjects; classified according to their Body Mass Index (BMI) and Waist Circumference (WC) into three main groups: Group 1: included 27 obese diabetic subjects Group 2: included 28 obese non diabetic subjects. Group 3: included 19 healthy non-obese subjects, serving as control. All patients were assessed for Insulin Resistance (IR) index by HOMA-IR and Assessment of B cell function by HOMA-β, RBP4. Results: RBP4 was significantly higher in group 1 and group 2 compared to group 3(p˃0.05) and was nonsignificant in group 1 compared to group 2. There was non-significant correlation between RBP4 & (anthropometric parameters, lipid profile, FBG, 2HPP, HBA1C, FI, HOMA-IR, HOMA-B) in group 1. RBP4 was significantly negative correlated with (BW, HDL) and significant positive correlated with FI, HOMA-IR in the group 2. In viscerally obese subjects HOMA-B% was lower than diabetes group and control group. Conclusion: RBP4 was correlated to insulin resistance in viscerally obese subjects. Viscerally obese subjects had impaired B cell function they are liable for type 2 diabetes and other metabolic risks